Research ArticleCancer

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

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Science Translational Medicine  10 May 2017:
Vol. 9, Issue 389, eaal3604
DOI: 10.1126/scitranslmed.aal3604

Article Information

vol. 9 no. 389

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 1, 2016
  • Resubmitted November 7, 2016
  • Accepted for publication March 16, 2017

Author Information

  1. Sean P. Arlauckas1,2,3,*,
  2. Christopher S. Garris1,4,*,
  3. Rainer H. Kohler1,
  4. Maya Kitaoka5,
  5. Michael F. Cuccarese1,
  6. Katherine S. Yang1,
  7. Miles A. Miller1,2,
  8. Jonathan C. Carlson1,
  9. Gordon J. Freeman6,
  10. Robert M. Anthony5,
  11. Ralph Weissleder1,2,3 and
  12. Mikael J. Pittet1,2,
  1. 1Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.
  2. 2Department of Radiology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.
  3. 3Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
  4. 4Graduate Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.
  5. 5Center for Immunology and Infectious Disease, Massachusetts General Hospital, 149 8th Street, Charlestown, MA 02129, USA.
  6. 6Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. Email: mpittet{at}mgh.harvard.edu
    • * These authors contributed equally to this work.

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