Contents

19 April 2017
Vol 9, Issue 386
  • Perspective

  • Research Articles

    • Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice

      Glycosaminoglycan-based hydrogels scavenge proinflammatory chemokines, reduce the influx of immune cells, and improve the healing of chronic wounds.

    • Improving genetic diagnosis in Mendelian disease with transcriptome sequencing

      Transcriptome sequencing improves the diagnostic rate for Mendelian disease in patients for whom genetic analysis has not returned a diagnosis.

    • RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

      Activation of the RIG-I or STING pathways results in a type I interferon response that protects gut integrity after irradiation- or immune-induced tissue injury.

    • Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

      Administration of an anti-tau antibody to transgenic mice expressing human tau and to patients with tauopathy increased the concentration of tau in plasma.

  • Editors' Choice

About The Cover

Cover image expansion

ONLINE COVER Heparin Hydrogel Helps Heal Wounds. Inflammatory chemokines contribute to poor wound healing. To improve wound healing, Lohmann et al. devised a hydrogel material that scavenges chemokines. This image shows the heparin (yellow) glycosaminoglycan-modified hydrogel (gray network) applied to a skin wound, where it sequesters chemokines (red) secreted by an immune cell (white and purple). The hydrogel captured inflammatory chemokines—but not growth factors beneficial for wound healing—from wound fluids isolated from human venous leg ulcers. In a mouse model of delayed skin wound healing, the hydrogel reduced inflammation and hastened tissue formation, revascularization, and wound closure. These results suggest capturing chemokines could help chronic wounds heal. [CREDIT: ZOLTÁN TANCZIK/VOR WERBEAGENTUR GMBH AND LUCAS SCHIRMER, UWE FREUDENBERG, CARSTEN WERNER/LEIBNIZ INSTITUTE OF POLYMER RESEARCH DRESDEN]