Editors' ChoiceImmunotherapy

Combination of an oncolytic virus with PD-L1 blockade keeps cancer in check

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Science Translational Medicine  19 Apr 2017:
Vol. 9, Issue 386, eaan2781
DOI: 10.1126/scitranslmed.aan2781

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Abstract

An oncolytic vaccinia virus expressing CXCL11 combined with PD-L1 blockade significantly reduces tumor burden and improves survival in murine cancer models.

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