Research ArticleTAUOPATHIES

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

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Science Translational Medicine  19 Apr 2017:
Vol. 9, Issue 386, eaal2029
DOI: 10.1126/scitranslmed.aal2029

Article Information

vol. 9 no. 386

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History: 
  • Received for publication May 15, 2016
  • Resubmitted October 14, 2016
  • Accepted for publication January 13, 2017

Author Information

  1. Kiran Yanamandra1,2,*,
  2. Tirth K. Patel1,*,
  3. Hong Jiang1,
  4. Suzanne Schindler1,
  5. Jason D. Ulrich1,
  6. Adam L. Boxer3,
  7. Bruce L. Miller3,
  8. Diana R. Kerwin4,
  9. Gilbert Gallardo1,
  10. Floy Stewart1,
  11. Mary Beth Finn1,
  12. Nigel J. Cairns1,
  13. Philip B. Verghese5,
  14. Ilana Fogelman5,
  15. Tim West5,
  16. Joel Braunstein5,
  17. Grace Robinson1,
  18. Jennifer Keyser1,
  19. Joseph Roh1,
  20. Stephanie S. Knapik5,
  21. Yan Hu5 and
  22. David M. Holtzman1,
  1. 1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
  2. 2AbbVie Inc. Foundational Neuroscience Center, Cambridge, MA 02139, USA.
  3. 3Clinical Trials Program, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
  4. 4Texas Alzheimer’s and Memory Disorders, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA.
  5. 5C2N Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.
  1. Corresponding author. Email: holtzman{at}neuro.wustl.edu
    • * These authors contributed equally to this work.

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