Research ArticleWound Healing

Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice

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Science Translational Medicine  19 Apr 2017:
Vol. 9, Issue 386, eaai9044
DOI: 10.1126/scitranslmed.aai9044

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Capturing chemokines in chronic wounds

Chronic, poor healing wounds are characterized by the lack of resolution of initial proinflammatory signaling present during acute injury. Lohmann et al. designed a synthetic hydrogel wound dressing based on heparin, a glycosaminoglycan that can bind and sequester chemokines. The hydrogel mopped up inflammatory chemokines such as MCP-1 and IL-8 from fluid from patients’ chronic venous leg ulcers in vitro and inhibited neutrophil and monocyte migration. Applying the hydrogel to skin wounds in diabetic mice improved wound healing and vascularization and reduced inflammation more effectively than the FDA-approved hydrogel Promogran. Capturing chemokines may be an effective strategy to promote tissue regeneration in chronic wounds.