Research ArticleGraft-Versus-Host Disease

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

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Science Translational Medicine  19 Apr 2017:
Vol. 9, Issue 386, eaag2513
DOI: 10.1126/scitranslmed.aag2513

Article Information

vol. 9 no. 386

PubMed: 
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History: 
  • Received for publication September 8, 2015
  • Resubmitted May 30, 2016
  • Accepted for publication January 18, 2017

Author Information

  1. Julius C. Fischer1,*,
  2. Michael Bscheider1,*,,
  3. Gabriel Eisenkolb1,2,*,
  4. Chia-Ching Lin1,
  5. Alexander Wintges1,
  6. Vera Otten1,
  7. Caroline A. Lindemans3,4,
  8. Simon Heidegger1,
  9. Martina Rudelius5,
  10. Sébastien Monette6,
  11. Kori A. Porosnicu Rodriguez2,
  12. Marco Calafiore4,
  13. Sophie Liebermann2,
  14. Chen Liu7,
  15. Stefan Lienenklaus8,
  16. Siegfried Weiss9,
  17. Ulrich Kalinke8,
  18. Jürgen Ruland10,11,12,
  19. Christian Peschel1,
  20. Yusuke Shono2,
  21. Melissa Docampo2,
  22. Enrico Velardi2,
  23. Robert R. Jenq4,
  24. Alan M. Hanash4,
  25. Jarrod A. Dudakov2,,
  26. Tobias Haas1,§,
  27. Marcel R. M. van den Brink2,4,§,|| and
  28. Hendrik Poeck1,2,§,||
  1. 1III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  2. 2Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  3. 3Pediatric Blood and Bone Marrow Transplant Program, University Medical Center Utrecht, Utrecht, Netherlands.
  4. 4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  5. 5Institute of Pathology, University of Wuerzburg and Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany.
  6. 6Tri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Rockefeller University, and Weill Cornell Medical College, New York, NY 10065, USA.
  7. 7Department of Pathology and Laboratory Medicine, New Jersey Medical School and Robert Wood Johnson Medical School, Rutgers University, Newark, NJ 08903, USA.
  8. 8Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.
  9. 9Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  10. 10Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  11. 11German Cancer Consortium (DKTK), Heidelberg, Germany.
  12. 12German Center for Infection Research (DZIF), partner site Munich, Munich, Germany.
  1. ||Corresponding author. Email: hendrik.poeck{at}tum.de (H.P.); m-van-den-brink{at}ski.mskcc.org (M.R.M.v.d.B.)
    • * These authors contributed equally to this work.

    • Present address: Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

    • Present address: Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.

    • § These authors contributed equally to this work.

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