PerspectiveDRUG DESIGN

Clinical chemoproteomics—Opportunities and obstacles

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Science Translational Medicine  19 Apr 2017:
Vol. 9, Issue 386, eaaf7951
DOI: 10.1126/scitranslmed.aaf7951

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Abstract

Chemoproteomics is the large-scale study of proteins using chemical methods. Although chemoproteomic techniques are becoming commonplace in preclinical research, few examples have found clinical utility. We explore the prospects for advancing chemoproteomics into the clinical setting to understand drug-target interactions and to identify new therapeutically relevant targets.

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