PerspectiveCardiovascular Disease

Cardiac regeneration: All work and no repair?

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Science Translational Medicine  29 Mar 2017:
Vol. 9, Issue 383, eaad9019
DOI: 10.1126/scitranslmed.aad9019

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Structural changes in the developing heart may influence the limited regenerative capacity of the adult heart. We examine how the workload exerted on the adult mammalian heart may limit regenerative capability and discuss recent therapies that demonstrate beneficial effects through unloading the heart.

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