Research ArticleHIV

Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

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Science Translational Medicine  15 Mar 2017:
Vol. 9, Issue 381, eaai7514
DOI: 10.1126/scitranslmed.aai7514

Article Information

vol. 9 no. 381

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History: 
  • Received for publication August 6, 2016
  • Resubmitted August 18, 2016
  • Accepted for publication January 31, 2017

Author Information

  1. Mattia Bonsignori1,2,*,,
  2. Edward F. Kreider3,,
  3. Daniela Fera4,,
  4. R. Ryan Meyerhoff1,2,,
  5. Todd Bradley1,2,,
  6. Kevin Wiehe1,2,
  7. S. Munir Alam1,2,
  8. Baptiste Aussedat5,
  9. William E. Walkowicz5,
  10. Kwan-Ki Hwang2,
  11. Kevin O. Saunders2,6,
  12. Ruijun Zhang2,
  13. Morgan A. Gladden2,
  14. Anthony Monroe2,
  15. Amit Kumar2,
  16. Shi-Mao Xia2,
  17. Melissa Cooper2,
  18. Mark K. Louder7,
  19. Krisha McKee7,
  20. Robert T. Bailer7,
  21. Brendan W. Pier4,
  22. Claudia A. Jette4,
  23. Garnett Kelsoe2,8,
  24. Wilton B. Williams1,2,
  25. Lynn Morris9,
  26. John Kappes10,
  27. Kshitij Wagh11,
  28. Gift Kamanga12,,
  29. Myron S. Cohen13,
  30. Peter T. Hraber11,
  31. David C. Montefiori2,6,
  32. Ashley Trama2,
  33. Hua-Xin Liao1,2,
  34. Thomas B. Kepler14,
  35. M. Anthony Moody2,8,15,
  36. Feng Gao1,2,
  37. Samuel J. Danishefsky5,
  38. John R. Mascola7,
  39. George M. Shaw3,
  40. Beatrice H. Hahn3,
  41. Stephen C. Harrison4,
  42. Bette T. Korber11,*, and
  43. Barton F. Haynes1,2,*,
  1. 1Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  2. 2Duke Human Vaccine Institute, Durham, NC 27710, USA.
  3. 3Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  4. 4Laboratory of Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  5. 5Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  6. 6Department of Surgery, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  7. 7Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  8. 8Department of Immunology, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  9. 9National Institute for Communicable Diseases, Johannesburg 2131, South Africa.
  10. 10Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  11. 11Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
  12. 12University of North Carolina Project, Kamuzu Central Hospital, Lilongwe, Malawi.
  13. 13Departments of Medicine, Epidemiology, and Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.
  14. 14Department of Microbiology and Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.
  15. 15Department of Pediatrics, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  1. *Corresponding author. Email: mattia.bonsignori{at}dm.duke.edu (M.B.); btk{at}lanl.gov (B.T.K.); barton.haynes{at}dm.duke.edu (B.F.H.)
    • These authors contributed equally to this work.

    • Present address: FHI 360, Lilongwe, Malawi.

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