Research ArticleCancer

Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

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Science Translational Medicine  15 Mar 2017:
Vol. 9, Issue 381, eaaf2968
DOI: 10.1126/scitranslmed.aaf2968

Article Information

vol. 9 no. 381

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication 31 October 2014.
  • Resubmitted 25 January 2016.
  • Accepted for publication 7 December 2016.

Author Information

  1. Sharareh Gholamin1,2,*,,
  2. Siddhartha S. Mitra1,2,*,,
  3. Abdullah H. Feroze1,§,
  4. Jie Liu3,||,
  5. Suzana A. Kahn1,2,
  6. Michael Zhang1,
  7. Rogelio Esparza1,
  8. Chase Richard1,,
  9. Vijay Ramaswamy4,5,
  10. Marc Remke4,5,6,
  11. Anne K. Volkmer2,7,
  12. Stephen Willingham2,#,
  13. Anitha Ponnuswami8,
  14. Aaron McCarty2,
  15. Patricia Lovelace2,
  16. Theresa A. Storm2,
  17. Simone Schubert8,
  18. Gregor Hutter1,**,
  19. Cyndhavi Narayanan3,
  20. Pauline Chu9,
  21. Eric H. Raabe10,
  22. Griffith Harsh IV11,
  23. Michael D. Taylor5,
  24. Michelle Monje1,2,8,
  25. Yoon-Jae Cho12,
  26. Ravi Majeti2,3,
  27. Jens P. Volkmer2,||,
  28. Paul G. Fisher8,
  29. Gerald Grant1,
  30. Gary K. Steinberg11,
  31. Hannes Vogel13,
  32. Michael Edwards1,
  33. Irving L. Weissman2,13,†† and
  34. Samuel H. Cheshier1,2,,††
  1. 1Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children’s Hospital, Stanford University School of Medicine, Stanford, CA 94305, USA.
  2. 2Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Ludwig Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  3. 3Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  4. 4Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  5. 5Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  6. 6Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
  7. 7Department of Gynecology and Obstetrics, University of Düsseldorf, 40225 Düsseldorf, Germany.
  8. 8Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
  9. 9Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  10. 10Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  11. 11Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  12. 12Department of Pediatrics and Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97231, USA.
  13. 13Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  1. Corresponding author: Email: ssmitra{at}stanford.edu (S.S.M.); cheshier{at}stanford.edu (S.H.C.)
    • * These authors contributed equally to this work.

    • Present address: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91106, USA.

    • § Present address: Department of Neurological Surgery, University of Washington Medical Center, 325 9th Avenue, Campus Box 359924, Seattle, WA 98104, USA.

    • || Present address: Forty Seven Inc., Menlo Park, CA 94025, USA.

    • Present address: Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

    • # Present address: Corvus Pharmaceuticals, Burlingame, CA 94010, USA.

    • ** Present address: Department of Neurosurgery, University Hospital Basel, Spitalstrasse 21, CH-4031 Basel, Switzerland.

    • †† These authors are co-senior authors.

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