Editors' ChoiceCancer

Winter is coming: Tumor cells go into hibernation

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Science Translational Medicine  15 Feb 2017:
Vol. 9, Issue 377, eaam6063
DOI: 10.1126/scitranslmed.aam6063

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Abstract

In response to hypoxia in the primary tumor microenvironment, tumor cells induce a state of dormancy enabling their persistence at metastatic sites and resistance to therapy.

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