Research ArticleMetabolic Disease

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

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Science Translational Medicine  15 Feb 2017:
Vol. 9, Issue 377, eaai8700
DOI: 10.1126/scitranslmed.aai8700

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Fasting: More than a fad

Mice that fast periodically are healthier, metabolically speaking. To explore whether fasting can help people as well, Wei et al. studied 71 people who either consumed a fasting-mimicking diet for 5 days each month for 3 months or maintained their normal diet for 3 months and then switched to the fasting schedule. The fasting-like diet reduced body weight and body fat, lowered blood pressure, and decreased the hormone IGF-1, which has been implicated in aging and disease. A post hoc analysis replicated these results and also showed that fasting decreased BMI, glucose, triglycerides, cholesterol, and C-reactive protein (a marker for inflammation). These effects were generally larger in the subjects who were at greater risk of disease at the start of the study. A larger study is needed to replicate these results, but they raise the possibility that fasting may be a practical road to a healthy metabolic system.