Research ArticleTOXICITY SCREENING

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

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Science Translational Medicine  15 Feb 2017:
Vol. 9, Issue 377, eaaf2584
DOI: 10.1126/scitranslmed.aaf2584

Article Information

vol. 9 no. 377

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 14, 2016
  • Resubmitted July 21, 2016
  • Accepted for publication November 21, 2016

Author Information

  1. Arun Sharma1,2,3,*,
  2. Paul W. Burridge1,2,4,*,
  3. Wesley L. McKeithan1,5,6,
  4. Ricardo Serrano7,
  5. Praveen Shukla1,2,3,
  6. Nazish Sayed1,2,3,
  7. Jared M. Churko1,2,3,
  8. Tomoya Kitani1,2,3,
  9. Haodi Wu1,2,3,
  10. Alexandra Holmström1,2,3,
  11. Elena Matsa1,2,3,
  12. Yuan Zhang1,2,3,
  13. Anusha Kumar1,2,3,
  14. Alice C. Fan8,
  15. Juan C. del Álamo7,
  16. Sean M. Wu1,2,3,
  17. Javid J. Moslehi9,
  18. Mark Mercola1,3,5 and
  19. Joseph C. Wu1,2,3,
  1. 1Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  2. 2Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  3. 3Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  4. 4Department of Pharmacology and Center for Pharmacogenomics, Northwestern University School of Medicine, Chicago, IL 60611, USA.
  5. 5Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  6. 6Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  7. 7Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92092, USA.
  8. 8Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  9. 9Division of Cardiovascular Medicine, Cardio-Oncology Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
  1. Corresponding author. Email: joewu{at}stanford.edu
    • * These authors contributed equally to this work.

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