Vol 9, Issue 377
New insights into the pathophysiology of nodding syndrome, a form of childhood epilepsy associated with onchocerciasis, provide new opportunities for disease treatment and parasite control (Johnson et al.).
Patients with nodding syndrome have autoantibodies to leiomodin-1 that are neurotoxic and cross-react with proteins of the parasitic worm Onchocerca volvulus.
- High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
High-throughput screening of drugs with human induced pluripotent stem cell–derived cardiomyocytes reveals a “cardiac safety index.”
- Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection
Potent CD8+ T cells endowed with effector functions able to kill HIV-producing cells and reduce the seeding of the HIV reservoir are only detected at peak viremia in acute HIV infection.
- Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
A periodic fasting diet improves markers of metabolic dysfunction, particularly in people already at risk.
In response to hypoxia in the primary tumor microenvironment, tumor cells induce a state of dormancy enabling their persistence at metastatic sites and resistance to therapy.
- Erratum for the Report: “Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells” by W. Qasim, H. Zhan, S. Samarasinghe, S. Adams, P. Amrolia, S. Stafford, K. Butler, C. Rivat, G. Wright, K. Somana, S. Ghorashian, D. Pinner, G. Ahsan, K. Gilmour, G. Lucchini, S. Inglott, W. Mifsud, R. Chiesa, K. S. Peggs, L. Chan, F. Farzeneh, A. J. Thrasher, A. Vora, M. Pule, P. Veys