Research ArticleCancer

Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin

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Science Translational Medicine  08 Feb 2017:
Vol. 9, Issue 376, eaak9537
DOI: 10.1126/scitranslmed.aak9537

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Two bacteria can be better than one

In some cases, injecting tumors with specific bacteria can help eradicate the tumors by stimulating inflammation and triggering an antitumor immune response. A classic example of this is injection of bladder cancer with bacillus Calmette-Guérin, but more recent approaches have used bacteria such as Clostridium and Salmonella species. Building on the idea of antitumor bacterial therapy, Zheng et al. engineered a weakened strain of Salmonella typhimurium to produce the flagellin B protein from another bacterium, Vibrio vulnificus. The engineered bacteria induced an effective antitumor immune response, successfully treating tumors in several different mouse models with no evidence of toxicity.