Research ArticleHIV

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

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Science Translational Medicine  18 Jan 2017:
Vol. 9, Issue 373, eaag2285
DOI: 10.1126/scitranslmed.aag2285

Article Information

vol. 9 no. 373

PubMed: 
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History: 
  • Received for publication May 26, 2016
  • Accepted for publication December 22, 2016

Author Information

  1. Constantinos Petrovas1,*,,
  2. Sara Ferrando-Martinez1,*,
  3. Michael Y. Gerner2,,
  4. Joseph P. Casazza1,
  5. Amarendra Pegu3,
  6. Claire Deleage4,
  7. Arik Cooper3,
  8. Jason Hataye1,
  9. Sarah Andrews5,
  10. David Ambrozak1,
  11. Perla M. Del Río Estrada6,
  12. Eli Boritz7,
  13. Robert Paris8,
  14. Eirini Moysi1,
  15. Kristin L. Boswell1,
  16. Ezequiel Ruiz-Mateos9,
  17. Ilias Vagios10,
  18. Manuel Leal9,
  19. Yuria Ablanedo-Terrazas6,
  20. Amaranta Rivero6,
  21. Luz Alicia Gonzalez-Hernandez6,
  22. Adrian B. McDermott5,
  23. Susan Moir11,
  24. Gustavo Reyes-Terán6,
  25. Fernando Docobo9,
  26. Giuseppe Pantaleo12,
  27. Daniel C. Douek7,
  28. Michael R. Betts13,
  29. Jacob D. Estes4,
  30. Ronald N. Germain2,
  31. John R. Mascola3 and
  32. Richard A. Koup1
  1. 1Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  2. 2Laboratory of Systems Biology, Lymphocyte Biology Section, NIAID, NIH, Bethesda, MD 20892, USA.
  3. 3Virology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA.
  4. 4AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, BG 535, Post Office Box B, Frederick, MD 21702, USA.
  5. 5Immunology Core Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA.
  6. 6Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
  7. 7Human Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA.
  8. 8Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  9. 9Laboratory of Immunovirology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, Universidad de Sevilla, Consejo Superior de Investigaciones Cientificas, Sevilla 41013, Spain.
  10. 10Department of Histopathology, Venizeleio Hospital, Iraklion, Crete, Greece.
  11. 11Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
  12. 12Service of Immunology and Allergy, Service of Infectious Diseases, Department of Medicine and Swiss Vaccine Research Institute, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland.
  13. 13Department of Microbiology, Center for AIDS Research, and Institute for Immunology Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  1. Corresponding author. Email: petrovasc{at}mail.nih.gov
    • * These authors contributed equally to this work.

    • Present address: Department of Immunology, University of Washington, Seattle, WA 98109, USA.

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