Research ArticleMalaria

Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects

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Science Translational Medicine  04 Jan 2017:
Vol. 9, Issue 371, eaad9099
DOI: 10.1126/scitranslmed.aad9099

Article Information

vol. 9 no. 371

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History: 
  • Received for publication 22 November 2015.
  • Accepted for publication 21 November 2016.

Author Information

  1. James G. Kublin1,2,3,*,,
  2. Sebastian A. Mikolajczak1,*,
  3. Brandon K. Sack1,
  4. Matt E. Fishbaugher1,
  5. Annette Seilie4,
  6. Lisa Shelton1,
  7. Tracie VonGoedert1,
  8. Melike Firat1,
  9. Sara Magee1,
  10. Emma Fritzen1,
  11. Will Betz1,
  12. Heather S. Kain1,
  13. Dorender A. Dankwa1,
  14. Ryan W. J. Steel1,
  15. Ashley M. Vaughan1,
  16. D. Noah Sather1,
  17. Sean C. Murphy1,4,5 and
  18. Stefan H. I. Kappe1,2,
  1. 1Center for Infectious Disease Research, formerly Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA.
  2. 2Department of Global Health, University of Washington, Seattle, WA 98195, USA.
  3. 3Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109–1024, USA.
  4. 4Department of Laboratory Medicine, University of Washington, 1959 Northeast Pacific Street, NW150, Seattle, WA 98195–7110, USA.
  5. 5Center for Emerging and Re-emerging Infectious Diseases and Department of Microbiology, University of Washington, 750 Republican Street, E630, Seattle, WA 98109, USA.
  1. Corresponding author. Email: stefan.kappe{at}cidresearch.org (S.H.I.K.); jkublin{at}fredhutch.org (J.G.K.)
    • * These authors contributed equally to this work.

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