PerspectiveCancer

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

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Science Translational Medicine  26 Oct 2016:
Vol. 8, Issue 362, pp. 362ps17
DOI: 10.1126/scitranslmed.aaf9246

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Abstract

Poly(ADP-ribose) polymerase (PARP) inhibitors are the first DNA damage response targeted agents approved for cancer therapy. Here, we focus on their molecular mechanism of action by PARP “trapping” and what this means for both clinical monotherapy and combination with chemotherapeutic agents.

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