Research ArticleCancer

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

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Science Translational Medicine  19 Oct 2016:
Vol. 8, Issue 361, pp. 361ra138
DOI: 10.1126/scitranslmed.aag1711

Article Information

vol. 8 no. 361 361ra138

Print ISSN: 
Online ISSN: 
  • Received for publication May 18, 2016
  • Accepted for publication September 23, 2016

Author Information

  1. Juwon Park1,*,,
  2. Robert W. Wysocki1,2,3,*,
  3. Zohreh Amoozgar4,*,,
  4. Laura Maiorino1,5,*,
  5. Miriam R. Fein1,3,
  6. Julie Jorns6,
  7. Anne F. Schott6,
  8. Yumi Kinugasa-Katayama1,
  9. Youngseok Lee7,
  10. Nam Hee Won7,
  11. Elizabeth S. Nakasone1,5,
  12. Stephen A. Hearn8,
  13. Victoria Küttner1,
  14. Jing Qiu1,
  15. Ana S. Almeida1,
  16. Naiara Perurena1,§,
  17. Kai Kessenbrock9,
  18. Michael S. Goldberg4,10 and
  19. Mikala Egeblad1,
  1. 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  2. 2Medical Scientist Training Program, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
  3. 3Graduate Program in Genetics, Stony Brook University, Stony Brook, NY 11794, USA.
  4. 4Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  5. 5Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA.
  6. 6University of Michigan, Ann Arbor, MI 48109, USA.
  7. 7Department of Pathology, Korea University Anam Hospital, Seoul, South Korea.
  8. 8Cold Spring Harbor Laboratory Cancer Center, NCI Shared Resources and St. Giles Foundation Advanced Microscopy Center, Cold Spring Harbor, NY 11724, USA.
  9. 9University of California, Irvine, Irvine, CA 92697, USA.
  10. 10Department of Microbiology and Immunobiology at Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. Email: egeblad{at}
    • * These authors contributed equally to this work.

    • Present address: Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.

    • Present address: Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

    • § Present address: The Genetics Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.


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