Research ArticleHIV

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

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Science Translational Medicine  28 Sep 2016:
Vol. 8, Issue 358, pp. 358ra125
DOI: 10.1126/scitranslmed.aag1048

Article Information

vol. 8 no. 358 358ra125

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  • Received for publication May 10, 2016
  • Accepted for publication August 22, 2016

Author Information

  1. Maximilian Muenchhoff1,2,3,4,*,
  2. Emily Adland1,*,
  3. Owen Karimanzira5,
  4. Carol Crowther5,
  5. Matthew Pace6,7,8,
  6. Anna Csala1,
  7. Ellen Leitman1,
  8. Angeline Moonsamy1,
  9. Callum McGregor1,2,
  10. Jacob Hurst9,
  11. Andreas Groll10,
  12. Masahiko Mori1,
  13. Smruti Sinmyee1,
  14. Christina Thobakgale2,
  15. Gareth Tudor-Williams11,
  16. Andrew J. Prendergast12,
  17. Henrik Kloverpris13,14,
  18. Julia Roider1,2,13,
  19. Alasdair Leslie13,
  20. Delane Shingadia15,
  21. Thea Brits16,
  22. Samantha Daniels16,
  23. John Frater6,7,8,
  24. Christian B. Willberg7,8,
  25. Bruce D. Walker2,17,
  26. Thumbi Ndung’u2,13,17,18,
  27. Pieter Jooste16,
  28. Penny L. Moore5,19,20,
  29. Lynn Morris5,19,20 and
  30. Philip Goulder1,2,15,
  1. 1Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, University of Oxford, Oxford OX1 3SY, U.K.
  2. 2HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal (UKZN), Durban, South Africa.
  3. 3Max von Pettenkofer-Institute, Department of Virology, Ludwig-Maximilians-University Munich, Munich, Germany.
  4. 4German Center for Infection Research (DZIF), Partner Site Munich, Germany.
  5. 5Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
  6. 6Institute for Emerging Infections, Oxford Martin School, University of Oxford, Oxford, U.K.
  7. 7Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, U.K.
  8. 8Oxford National Institute of Health Research, Biomedical Research Centre, Oxford, U.K.
  9. 9Institute of Cancer Research, Old Brompton Road, London SW7 3RP, U.K.
  10. 10Department of Mathematics, Ludwig-Maximilians-University Munich, Theresienstrasse 39, 80333 Munich, Germany.
  11. 11Department of Paediatrics, Imperial College London, London, U.K.
  12. 12Blizard Institute, Queen Mary University of London, London, U.K.
  13. 13KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), University of KwaZulu-Natal (UKZN), 4001 Durban, South Africa.
  14. 14Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
  15. 15Department of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children, London, U.K.
  16. 16Paediatric Department, Kimberley Hospital, Northern Cape, South Africa.
  17. 17Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139–4307, USA.
  18. 18Max Planck Institute for Infection Biology, Berlin, Germany.
  19. 19Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  20. 20Center for the AIDS Programme of Research in South Africa (CAPRISA), 4001 Durban, South Africa.
  1. Corresponding author. Email: philip.goulder{at}
    • * These authors contributed equally to this work.


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