Research ArticleInflammation

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

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Science Translational Medicine  24 Aug 2016:
Vol. 8, Issue 353, pp. 353ra111
DOI: 10.1126/scitranslmed.aaf7483

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Naïve T cells nudged by lipid mediators

Specialized proresolving lipid mediators are known to modulate the innate immune system, and here, Chiurchiù et al. report that some of these lipid mediators can also inhibit human T cell activation. Incubation with lipid mediators increased naïve CD4+ T cell differentiation into regulatory T cells and suppressed differentiation of TH1 or TH17 cells. A mouse model that is unable to generate precursors for these lipid mediators also had an increase of TH1 and TH17 cells and relatively fewer regulatory T cells than wild-type mice. These results identify a potentially useful avenue of immunomodulation for steering T cell responses in inflammation or autoimmunity.