Vol 8, Issue 352
Precision medicine will be advanced by systematically integrating animal models of human disease, computational frameworks, and experimental preclinical strategies for validation of clinically actionable findings.
Manipulation of the Hippo signaling pathway with a reversible and selective small-molecule inhibitor of Hippo kinase MST1/2 provides a therapeutic option for tissue injury and repair.
- ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy
Corticosterone is as effective as cortisol for ACTH suppression but lacks metabolic adverse effects.