Comment on “Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice”

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Science Translational Medicine  03 Aug 2016:
Vol. 8, Issue 350, pp. 350le2
DOI: 10.1126/scitranslmed.aaf4379

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In ApcMin mice (an animal model of colorectal carcinogenesis) fed a high-fat diet, low doses of resveratrol suppress intestinal adenoma development more potently than high doses do; however, these findings appear affected by multiple confounding factors, as resveratrol alone added to a standard diet has opposite outcomes.

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