Research ArticleCystic Fibrosis

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

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Science Translational Medicine  22 Jun 2016:
Vol. 8, Issue 344, pp. 344ra84
DOI: 10.1126/scitranslmed.aad8278

Article Information

vol. 8 no. 344 344ra84

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication November 9, 2015
  • Accepted for publication June 4, 2016

Author Information

  1. Johanna F. Dekkers1,2,
  2. Gitte Berkers1,
  3. Evelien Kruisselbrink1,2,
  4. Annelotte Vonk1,2,
  5. Hugo R. de Jonge3,
  6. Hettie M. Janssens4,
  7. Inez Bronsveld5,
  8. Eduard A. van de Graaf5,
  9. Edward E. S. Nieuwenhuis6,
  10. Roderick H. J. Houwen6,
  11. Frank P. Vleggaar7,
  12. Johanna C. Escher8,
  13. Yolanda B. de Rijke9,
  14. Christof J. Majoor10,
  15. Harry G. M. Heijerman11,
  16. Karin M. de Winter–de Groot1,
  17. Hans Clevers12,
  18. Cornelis K. van der Ent1 and
  19. Jeffrey M. Beekman1,2,13,*
  1. 1Department of Pediatric Pulmonology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, 3584 EA Utrecht, Netherlands.
  2. 2Laboratory of Translational Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, 3584 EA Utrecht, Netherlands.
  3. 3Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 3015 CE Rotterdam, Netherlands.
  4. 4Department of Pediatric Pulmonology, Erasmus University Medical Center/Sophia Children’s Hospital, 3015 CN Rotterdam, Netherlands.
  5. 5Department of Pulmonology, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands.
  6. 6Department of Pediatric Gastroenterology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, 3584 EA Utrecht, Netherlands.
  7. 7Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands.
  8. 8Department of Pediatric Gastroenterology, Erasmus University Medical Center/Sophia Children’s Hospital, 3015 CN Rotterdam, Netherlands.
  9. 9Department of Clinical Chemistry, Erasmus University Medical Center/Sophia Children’s Hospital, 3015 CN Rotterdam, Netherlands.
  10. 10Department of Respiratory Medicine, Academic Medical Center, 1105 AZ Amsterdam, Netherlands.
  11. 11Department of Pulmonology and Cystic Fibrosis, Haga Teaching Hospital, 2545 CH The Hague, Netherlands.
  12. 12Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands.
  13. 13Regenerative Medicine Center Utrecht, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands.
  1. *Corresponding author. Email: j.beekman{at}umcutrecht.nl

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