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Research ArticleMicrobiome
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability
- Moran Yassour1,2,
- Tommi Vatanen1,3,
- Heli Siljander4,5,6,
- Anu-Maaria Hämäläinen7,
- Taina Härkönen4,5,
- Samppa J. Ryhänen4,5,
- Eric A. Franzosa8,
- Hera Vlamakis1,
- Curtis Huttenhower1,8,
- Dirk Gevers1,*,
- Eric S. Lander1,9,10,†,
- Mikael Knip4,5,6,11,†,
- on behalf of the DIABIMMUNE Study Group‡ and
- Ramnik J. Xavier1,2,12,13,†,§
- 1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
- 2Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
- 3Department of Computer Science, Aalto University School of Science, 02150 Espoo, Finland.
- 4Children’s Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
- 5Research Programs Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland.
- 6Department of Pediatrics, Tampere University Hospital, 33521 Tampere, Finland.
- 7Department of Pediatrics, Jorvi Hospital, Helsinki University Hospital, 02740 Espoo, Finland.
- 8Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
- 9Department of Biology, MIT, Cambridge, MA 02139, USA.
- 10Department of Systems Biology, Harvard Medical School, Boston, MA 02114, USA.
- 11Folkhälsan Research Center, 00290 Helsinki, Finland.
- 12Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
- 13Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA 02139, USA.
- ↵§Corresponding author. Email: xavier{at}molbio.mgh.harvard.edu
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Science Translational Medicine 15 Jun 2016:
Vol. 8, Issue 343, pp. 343ra81
DOI: 10.1126/scitranslmed.aad0917
Vol. 8, Issue 343, pp. 343ra81
DOI: 10.1126/scitranslmed.aad0917
Moran Yassour
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Tommi Vatanen
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.Department of Computer Science, Aalto University School of Science, 02150 Espoo, Finland.
Heli Siljander
Children’s Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.Research Programs Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland.Department of Pediatrics, Tampere University Hospital, 33521 Tampere, Finland.
Anu-Maaria Hämäläinen
Department of Pediatrics, Jorvi Hospital, Helsinki University Hospital, 02740 Espoo, Finland.
Taina Härkönen
Children’s Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.Research Programs Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland.
Samppa J. Ryhänen
Children’s Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.Research Programs Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland.
Eric A. Franzosa
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
Hera Vlamakis
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
Curtis Huttenhower
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
Dirk Gevers
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
Eric S. Lander
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.Department of Biology, MIT, Cambridge, MA 02139, USA.Department of Systems Biology, Harvard Medical School, Boston, MA 02114, USA.
Mikael Knip
Children’s Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.Research Programs Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland.Department of Pediatrics, Tampere University Hospital, 33521 Tampere, Finland.Folkhälsan Research Center, 00290 Helsinki, Finland.
Ramnik J. Xavier
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA 02139, USA.
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