Research ArticleMicrobiome

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

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Science Translational Medicine  15 Jun 2016:
Vol. 8, Issue 343, pp. 343ra81
DOI: 10.1126/scitranslmed.aad0917

Article Information

vol. 8 no. 343 343ra81

Print ISSN: 
Online ISSN: 
  • Received for publication August 7, 2015
  • Accepted for publication May 27, 2016

Author Information

  1. Moran Yassour1,2,
  2. Tommi Vatanen1,3,
  3. Heli Siljander4,5,6,
  4. Anu-Maaria Hämäläinen7,
  5. Taina Härkönen4,5,
  6. Samppa J. Ryhänen4,5,
  7. Eric A. Franzosa8,
  8. Hera Vlamakis1,
  9. Curtis Huttenhower1,8,
  10. Dirk Gevers1,*,
  11. Eric S. Lander1,9,10,,
  12. Mikael Knip4,5,6,11,,
  13. on behalf of the DIABIMMUNE Study Group and
  14. Ramnik J. Xavier1,2,12,13,,§
  1. 1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
  2. 2Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  3. 3Department of Computer Science, Aalto University School of Science, 02150 Espoo, Finland.
  4. 4Children’s Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
  5. 5Research Programs Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland.
  6. 6Department of Pediatrics, Tampere University Hospital, 33521 Tampere, Finland.
  7. 7Department of Pediatrics, Jorvi Hospital, Helsinki University Hospital, 02740 Espoo, Finland.
  8. 8Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
  9. 9Department of Biology, MIT, Cambridge, MA 02139, USA.
  10. 10Department of Systems Biology, Harvard Medical School, Boston, MA 02114, USA.
  11. 11Folkhälsan Research Center, 00290 Helsinki, Finland.
  12. 12Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  13. 13Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA 02139, USA.
  1. §Corresponding author. Email: xavier{at}
    • Co-senior authors.

    • * Present address: Janssen Human Microbiome Institute, Janssen Research and Development, Cambridge, MA 02142, USA.

    • The investigators in the DIABIMMUNE Study Group are listed in the Supplementary Materials.


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