Research ArticleAtherosclerosis

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

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Science Translational Medicine  06 Apr 2016:
Vol. 8, Issue 333, pp. 333ra50
DOI: 10.1126/scitranslmed.aad6100

Article Information

vol. 8 no. 333 333ra50

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History: 
  • Received for publication 11 October 2015.
  • Accepted for publication 18 February 2016.

Author Information

  1. Sebastian Zimmer1,*,
  2. Alena Grebe2,*,
  3. Siril S. Bakke2,3,4,
  4. Niklas Bode1,
  5. Bente Halvorsen5,
  6. Thomas Ulas6,
  7. Mona Skjelland7,
  8. Dominic De Nardo2,8,9,
  9. Larisa I. Labzin2,
  10. Anja Kerksiek10,
  11. Chris Hempel11,
  12. Michael T. Heneka12,
  13. Victoria Hawxhurst13,
  14. Michael L. Fitzgerald13,
  15. Jonel Trebicka14,15,
  16. Ingemar Björkhem16,
  17. Jan-Åke Gustafsson17,
  18. Marit Westerterp18,
  19. Alan R. Tall18,
  20. Samuel D. Wright19,
  21. Terje Espevik4,
  22. Joachim L. Schultze3,6,
  23. Georg Nickenig1,
  24. Dieter Lütjohann10 and
  25. Eicke Latz2,3,4,20,
  1. 1Medizinische Klinik und Poliklinik II, University Hospital Bonn, 53105 Bonn, Germany.
  2. 2Institute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany.
  3. 3German Center of Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
  4. 4Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
  5. 5Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, 0424 Oslo, Norway.
  6. 6Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany.
  7. 7Department of Neurology, Oslo University Hospital Rikshospitalet, 0424 Oslo, Norway.
  8. 8Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  9. 9Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
  10. 10Institute of Clinical Chemistry und Clinical Pharmacology, University Hospital Bonn, 53105 Bonn, Germany.
  11. 11Addi and Cassi Fund, Reno, NV 89511, USA.
  12. 12Clinic and Polyclinic for Neurology, University Hospital Bonn, 53105 Bonn, Germany.
  13. 13Lipid Metabolism Unit, Center for Computational and Integrative Biology, Boston, MA 02114, USA.
  14. 14Medizinische Klinik und Poliklinik I, University Hospital Bonn, 53105 Bonn, Germany.
  15. 15Faculty of Health Sciences, University of Southern Denmark Campusvej 55, DK-5230 Odense M, Denmark.
  16. 16Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, 141 86 Huddinge, Sweden.
  17. 17Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77004, USA.
  18. 18Department of Medicine, Columbia University, New York, NY 10032, USA.
  19. 19CSL Behring, King of Prussia, PA 19406, USA.
  20. 20Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  1. Corresponding author. E-mail: eicke.latz{at}uni-bonn.de
    • * These authors contributed equally to this work.

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