FocusAutoimmune Disease

Metabolic control of arthritis: Switch pathways to treat

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Science Translational Medicine  23 Mar 2016:
Vol. 8, Issue 331, pp. 331fs8
DOI: 10.1126/scitranslmed.aaf4953

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A shunting of glucose metabolism to the pentose phosphate pathway in rheumatoid arthritis T cells causes exhaustion of oxidants, enhanced cell proliferation, and differentiation toward the T helper 1 (TH1) and TH17 programs (Yang et al., this issue).

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