09 March 2016
Vol 8, Issue 329

About The Cover

Cover image expansion

ONLINE COVER Another Brick in the Wall. Compounds called tarocins block the first step in the biosynthesis of techoic acid, a key component of the bacterial cell wall. In the face of loss of this crucial building brick, bacterial defense against β-lactam antibiotics crumbles such that even methicillin-resistant Staphylococcus aureus succumbs to attack by these antibacterial drugs (Lee et al.) Although tarocins do not themselves have bactericidal activity, they provide a powerful boost to bacterial killing when combined with traditional β-lactam antibiotics, opening up a new avenue in the fight against bacterial infection. [CREDIT: M. ANGELO/CORBIS]