Research ArticleCancer

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

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Science Translational Medicine  02 Mar 2016:
Vol. 8, Issue 328, pp. 328ra28
DOI: 10.1126/scitranslmed.aac8228

Article Information

vol. 8 no. 328 328ra28

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 18, 2015
  • Accepted for publication January 25, 2016

Author Information

  1. Carl Koschmann1,2,
  2. Anda-Alexandra Calinescu2,
  3. Felipe J. Nunez2,
  4. Alan Mackay3,
  5. Janet Fazal-Salom3,
  6. Daniel Thomas2,
  7. Flor Mendez2,
  8. Neha Kamran2,
  9. Marta Dzaman2,
  10. Lakshman Mulpuri2,
  11. Johnathon Krasinkiewicz2,
  12. Robert Doherty2,
  13. Rosemary Lemons2,
  14. Jacqueline A. Brosnan-Cashman4,
  15. Youping Li2,
  16. Soyeon Roh2,
  17. Lili Zhao5,
  18. Henry Appelman6,
  19. David Ferguson6,
  20. Vera Gorbunova7,
  21. Alan Meeker8,
  22. Chris Jones3,
  23. Pedro R. Lowenstein2 and
  24. Maria G. Castro2,*
  1. 1Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  2. 2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  3. 3Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, London SM2 5NG, UK.
  4. 4Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA.
  5. 5Department of Biostatistics, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  6. 6Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  7. 7Department of Biology, University of Rochester, Rochester, NY 14627, USA.
  8. 8Departments of Pathology and Urology, Johns Hopkins University, Baltimore, MD 21287, USA.
  1. *Corresponding author. E-mail: mariacas{at}med.umich.edu

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