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Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase

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Science Translational Medicine  10 Feb 2016:
Vol. 8, Issue 325, pp. 325ra18
DOI: 10.1126/scitranslmed.aad6833

Article Information

vol. 8 no. 325 325ra18

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History: 
  • Received for publication October 20, 2015
  • Accepted for publication December 29, 2015

Author Information

  1. Rachael Jarrett1,
  2. Mariolina Salio1,
  3. Antonia Lloyd-Lavery1,
  4. Sumithra Subramaniam1,
  5. Elvire Bourgeois2,
  6. Charles Archer1,
  7. Ka Lun Cheung1,
  8. Clare Hardman1,
  9. David Chandler1,
  10. Maryam Salimi1,
  11. Danuta Gutowska-Owsiak1,
  12. Jorge Bernardino de la Serna1,
  13. Padraic G. Fallon3,4,5,
  14. Helen Jolin6,
  15. Andrew Mckenzie6,
  16. Andrzej Dziembowski7,
  17. Ewa Izabela Podobas7,
  18. Wojciech Bal7,
  19. David Johnson8,
  20. D. Branch Moody2,
  21. Vincenzo Cerundolo1,* and
  22. Graham Ogg1,*,
  1. 1Medical Research Council (MRC) Human Immunology Unit, National Institute for Health Research Biomedical Research Centre, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
  2. 2Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02114, USA.
  3. 3Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland.
  4. 4Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James’s Hospital, Dublin 2, Ireland.
  5. 5National Children’s Research Centre, Our Lady’s Children’s Hospital, Dublin 12, Ireland.
  6. 6MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
  7. 7Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland.
  8. 8Department of Plastic and Reconstructive Surgery, John Radcliffe Hospital, Oxford University Hospitals National Health Service Trust, Oxford OX3 9DU, UK.
  1. Corresponding author. E-mail: graham.ogg{at}ndm.ox.ac.uk
    • * These authors contributed equally to this work.

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