ReviewLiver disease

The intersection of nonalcoholic fatty liver disease and obesity

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Science Translational Medicine  27 Jan 2016:
Vol. 8, Issue 323, pp. 323rv1
DOI: 10.1126/scitranslmed.aad8390

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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and recently emerged as the most rapidly increasing indication for liver transplant. Although obesity is a risk factor for NAFLD, overlap between these two entities is incompletely understood. We highlight recent insights into the pathogenesis of human NAFLD in relation to obesity and discuss advances in the diagnosis and treatment of NAFLD.

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