27 January 2016
Vol 8, Issue 323
  • Contents

    • Editorial

    • Perspectives

    • Research Articles

      • Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans

        Targeting apoB synthesis with mipomersen (KYNAMRO) can be effective for lowering plasma levels of apoB lipoproteins without reducing the secretion of VLDL.

      • USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

        Deficiency of USF1 protects against obesity, insulin resistance, and cardiovascular disease in mice and humans, and induces brown adipose tissue to burn triglycerides and glucose.

    • Reviews

    • Editors' Choice

      • Advance warning

        An algorithm transforms heart rate variability data into a warning sign for imminent epileptic seizure.

      • Hiding in plain sight

        Even when it seems like we humans are winning against Mycobacterium tuberculosis, we probably aren’t.

      • A wealth of cells

        Expanding hematopoietic stem cells from umbilical cord blood with an aryl hydrocarbon antagonist could improve stem cell therapy.

      • Stemming the tide of ALS

        Mesenchymal stem cells engineered to secrete neurotrophic growth factors appear to be safe and show modest benefit in patients with amyotrophic lateral sclerosis.

      • No lung cancer left behind

        Molecular profiling of lung cancer is feasible at the population scale.

About The Cover

Cover image expansion

ONLINE COVER A Growing Problem. This cover image, depicting an overweight Earth trying to slim down, illustrates the global nature of the ongoing obesity epidemic. This week's special issue on obesity and metabolism presents some of the latest scientific advances and potential therapeutic directions in this field. [CREDIT: JUSUN/iSTOCKPHOTO]