Research ArticleImmunotherapy

Early memory phenotypes drive T cell proliferation in patients with pediatric malignancies

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Science Translational Medicine  06 Jan 2016:
Vol. 8, Issue 320, pp. 320ra3
DOI: 10.1126/scitranslmed.aad5222

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Young blood for immunotherapy

Adoptive cell therapies with engineered T cells have shown promising results in patients whose cancer is recalcitrant to other therapies. However, chemotherapy can inhibit both the expansion and function of T cells, limiting the success of this approach. Now, Singh et al. report that T cell populations enriched for early lineage cells expanded better in vitro. These cells could be specifically enriched by collecting T cells at time points diametric to chemotherapy administration and expanded in vitro with targeted culture methods. These data suggest that enriching early lineage cells may increase the number of patients who may benefit from engineered T cell therapy.