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Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

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Science Translational Medicine  23 Dec 2015:
Vol. 7, Issue 319, pp. 319ra206
DOI: 10.1126/scitranslmed.aad5752

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Passive aggression for HIV

Antibodies that neutralize HIV could add to the therapeutic arsenal to prevent and treat disease. Lynch et al. have now tested one such antibody—VRC01—in HIV-infected individuals. Although little difference was observed in viral reservoir in individuals on antiretroviral therapy, plasma viremia was reduced in untreated subjects with a single infusion of VRC01, preferentially suppressing neutralization-sensitive strains. Passive immunization with neutralizing antibodies could therefore aid in viral suppression in HIV-infected individuals.