Research ArticleCancer

Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade

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Science Translational Medicine  25 Nov 2015:
Vol. 7, Issue 315, pp. 315ra188
DOI: 10.1126/scitranslmed.aac4925

Article Information

vol. 7 no. 315 315ra188

PubMed: 
Print ISSN: 
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History: 
  • Received for publication May 14, 2015
  • Accepted for publication October 15, 2015

Author Information

  1. Philipp Müller1,*,
  2. Matthias Kreuzaler1,
  3. Tarik Khan2,,
  4. Daniela S. Thommen1,3,
  5. Kea Martin1,
  6. Katharina Glatz4,
  7. Spasenija Savic4,
  8. Nadia Harbeck5,6,
  9. Ulrike Nitz6,7,8,
  10. Oleg Gluz6,8,
  11. Michael von Bergwelt-Baildon9,
  12. Hans Kreipe6,10,
  13. Sai Reddy2,
  14. Matthias Christgen6,10 and
  15. Alfred Zippelius1,3,*
  1. 1Department of Biomedicine, University Hospital and University of Basel, CH-4031 Basel, Switzerland.
  2. 2Department of Biosystems Science and Engineering, ETH Zürich, CH-4058 Basel, Switzerland.
  3. 3Department of Medical Oncology, University Hospital Basel, CH-4031 Basel, Switzerland.
  4. 4Institute of Pathology, University Hospital Basel, CH-4031 Basel, Switzerland.
  5. 5Breast Center, Department of Obstetrics and Gynecology, University of Munich, D-81377 Munich, Germany.
  6. 6West German Study Group, D-41061 Mönchengladbach, Germany.
  7. 7Women’s Clinic, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
  8. 8Breast Center Niederrhein, Ev. Bethesda Hospital, D-41061 Mönchengladbach, Germany.
  9. 9First Department of Internal Medicine, University of Cologne, D-50937 Cologne, Germany.
  10. 10Institute of Pathology, Hannover Medical School, D-30625 Hannover, Germany.
  1. *Corresponding author. E-mail: ph.mueller{at}unibas.ch (P.M.); alfred.zippelius{at}usb.ch (A.Z.)
  • Present address: Pharmaceutical Development and Supplies, Pharma Technical Development, F. Hoffmann–La Roche Ltd., 4070 Basel, Switzerland; Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, 4058 Basel, Switzerland.

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