Comment on “Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2”

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Science Translational Medicine  18 Nov 2015:
Vol. 7, Issue 314, pp. 314le2
DOI: 10.1126/scitranslmed.aad2353

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Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children, as suggested by Ahmed et al.? Using newly developed mouse models to report and inactivate hypocretin receptor expression, Vassalli et al. now show that hypocretin neurons (whose loss causes narcolepsy) do not express hypocretin autoreceptors, raising questions to the interpretation of Ahmed et al.’s findings.

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