Contents

04 November 2015
Vol 7, Issue 312

About The Cover

Cover image expansion

ONLINE COVER Spilling Cancer's Secrets. This image shows a blood vessel adjacent to a tumor, with some of the tumor contents spilling out into the circulation. Just as a tumor contains a mixture of live and dead cells, the blood vessel contains live and dead tumor cells, as well as circulating DNA and RNA from the tumor. In this issue, Romanel et al. demonstrate that genetic changes associated with resistance to hormonal treatment can be detected in circulating tumor DNA from prostate cancer patients before they even start therapy, suggesting that analysis of circulating DNA may be able to guide the choice of treatment. A Focus by Schweizer and Antonarakis discusses the implications of this finding. [CREDIT: H. MCDONALD/SCIENCE TRANSLATIONAL MEDICINE]