FocusMICROENVIRONMENT

Aging as a driver of leukemogenesis

Science Translational Medicine  23 Sep 2015:
Vol. 7, Issue 306, pp. 306fs38
DOI: 10.1126/scitranslmed.aac4428

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Abstract

Certain leukemia-initiating mutations drive expansion of hemopoietic clones specifically under the selection pressures that prevail in an aged microenvironment.

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