Targeting the glucocorticoid receptor in breast and prostate cancers

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Science Translational Medicine  16 Sep 2015:
Vol. 7, Issue 305, pp. 305ps19
DOI: 10.1126/scitranslmed.aac7531

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Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor’s concomitant androgen or estrogen receptor activity.

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