Contents
16 September 2015
Vol 7, Issue 305
Vol 7, Issue 305
Contents
Perspectives
- Targeting the glucocorticoid receptor in breast and prostate cancers
The glucocorticoid receptor has a context-dependent role in breast and prostate cancers and may serve as a therapeutic target.
- Parkinson’s disease: From human genetics to clinical trials
In this Perspective, van der Brug and colleagues discuss the road from elucidating the genetics of Parkinson's disease through drug discovery to clinical trials, mapping the challenges along the way.
Research Articles
- Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection
A monkey model of human pegivirus infection provides new insights into the biology of this virus.
- CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine
Delivery of resiniferatoxin under CT guidance around lumbar dorsal root ganglia in pigs resulted in selective deletion of nociceptive neurons and lasting analgesia.
- Effects of caffeine on the human circadian clock in vivo and in vitro
Caffeine delays the human circadian clock and affects cellular timekeeping through an adenosine receptor–dependent mechanism.
- Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer
Avoiding irradiation of the region of the parotid gland containing stem cells reduces the risk of xerostomia (dry mouth).
Editors' Choice
- Learning to expect the unexpected: Updating the cerebellum during voluntary movement
Motor learning is rapidly updated by cerebellar command.
- Nanoparticles, macroplanning
A nanoparticle EBV vaccine designed using structural biology outperformed current vaccine approaches in both mice and macaques.
- No longer aware of what cannot be remembered
Loss of awareness of a cognitive decline occurs before the onset of dementia and is associated with post mortem dementia pathology.
- Basket trials: Making sense of context
“Basket” clinical trials help identify drug activity in multiple tumor types and allow for the influence of tumor lineage on drug sensitivity.
About The Cover
ONLINE COVER Pain-Free Pigs. The drug resiniferatoxin, an agonist of TRPV1 receptors, is a potent analgesic in a swine model of pain transmission, Brown et al.. Resiniferatoxin, delivered by computed-tomography guided injection to the dorsal root ganglia of swine, exerts its analgesic effect by killing off the nociceptive neurons expressing TRPV1 while preserving proprioceptive and somatosensory neurons that do not express this receptor. Treatment with resiniferatoxin rendered the pigs resistant to infrared laser heat stimuli that would normally induce a withdrawal response. Precise delivery of resiniferatoxin to sites of peripheral pain transmission may be a therapeutic approach for treating a variety of pain conditions in human patients. [CREDIT: MACDUFF EVERTON/CORBIS]