ReportsINSULIN RESISTANCE

Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men

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Science Translational Medicine  09 Sep 2015:
Vol. 7, Issue 304, pp. 304re7
DOI: 10.1126/scitranslmed.aac4765

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The irresistible effects of overfeeding

Obesity is very common in the United States and worldwide, and it is associated with a host of health problems collectively known as the metabolic syndrome. Insulin resistance is a key component of this syndrome, but the mechanism by which obesity promotes insulin resistance is not yet fully understood. Boden et al. studied a group of six healthy men who were subjected to overnutrition for 1 week while performing no physical activity. In that time, the men gained an average of 3.5 kg and showed signs of insulin resistance as well as oxidative stress. This process was associated with inactivation of GLUT4, a major insulin-facilitated glucose transporter, suggesting a potential approach for the development of future therapeutic agents.