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NS1: A corner piece in the dengue pathogenesis puzzle?

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Science Translational Medicine  09 Sep 2015:
Vol. 7, Issue 304, pp. 304fs37
DOI: 10.1126/scitranslmed.aad1255

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Soluble dengue virus NS1 protein induces proinflammatory immune responses via Toll-like receptor 4 and disrupts endothelial cell integrity, resulting in vascular leakage (Beatty et al. and Modhiran et al., this issue).

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