Contents

09 September 2015
Vol 7, Issue 304

About The Cover

Cover image expansion

ONLINE COVER You Give Me Fever. As suggested by its floating structure illustration, dengue virus nonstructural protein 1 (NS1) may take center stage in the battle against dengue hemorrhagic fever, according to a pair of studies in this week's issue. The life-threatening syndrome is characterized by cytokine storm, vascular leak, and toxic shock. Modhiran et al. and Beatty et al. have pinpointed NS1 as a driver of vascular leak via the innate immune Toll-like receptor 4, transforming NS1 into a probable therapeutic target and vaccine component. See the accompanying Focus by Thomas. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]