Research ArticleInfectious Disease

Efficacy of a virus-vectored vaccine against human and bovine respiratory syncytial virus infections

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Science Translational Medicine  12 Aug 2015:
Vol. 7, Issue 300, pp. 300ra127
DOI: 10.1126/scitranslmed.aac5757

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RSV vaccine cows infection

Respiratory syncytial virus (RSV) causes a severe lower respiratory tract disease that affects both children and the elderly. Vaccines have shown promise in rodents and nonhuman primates, but it remains unclear if these models reflect human RSV infection. Now, two papers by Taylor et al. and Green et al. translate one vaccine strategy first into calves, which are natural hosts of bovine RSV (BRSV), and then into humans in a phase 1 clinical trial. A prime-boost strategy protected against upper and lower respiratory tract infection and pulmonary disease induced by heterologous BRSV challenge in calves, and demonstrated safety and immunogenicity in humans. These data support further trials to test vaccine efficacy in human patients.