PerspectiveDrug Discovery

Developing predictive assays: The phenotypic screening “rule of 3”

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Science Translational Medicine  24 Jun 2015:
Vol. 7, Issue 293, pp. 293ps15
DOI: 10.1126/scitranslmed.aab1201

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Phenotypic drug discovery approaches can positively affect the translation of preclinical findings to patients. However, not all phenotypic assays are created equal. A critical question then follows: What are the characteristics of the optimal assays? We analyze this question and propose three specific criteria related to the disease relevance of the assay—system, stimulus, and end point—to help design the most predictive phenotypic assays.

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