Research ArticleCARDIOVASCULAR AGING

Vinculin network–mediated cytoskeletal remodeling regulates contractile function in the aging heart

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Science Translational Medicine  17 Jun 2015:
Vol. 7, Issue 292, pp. 292ra99
DOI: 10.1126/scitranslmed.aaa5843

Article Information

vol. 7 no. 292 292ra99

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 29, 2014
  • Accepted for publication May 26, 2015

Author Information

  1. Gaurav Kaushik1,*,
  2. Alice Spenlehauer1,,
  3. Ayla O. Sessions2,
  4. Adriana S. Trujillo3,
  5. Alexander Fuhrmann1,
  6. Zongming Fu4,
  7. Vidya Venkatraman5,
  8. Danielle Pohl1,,
  9. Jeremy Tuler1,
  10. Mingyi Wang6,
  11. Edward G. Lakatta6,
  12. Karen Ocorr7,
  13. Rolf Bodmer7,
  14. Sanford I. Bernstein3,
  15. Jennifer E. Van Eyk4,5,
  16. Anthony Cammarato4,§ and
  17. Adam J. Engler1,2,8,§
  1. 1Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
  2. 2Biomedical Sciences Program, University of California, San Diego, La Jolla, CA 92093, USA.
  3. 3Department of Biology, Heart Institute, and Molecular Biology Institute, San Diego State University, San Diego, CA 92182, USA.
  4. 4Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
  5. 5Advanced Clinical Biosystems Research Institute, Barbra Streisand Women’s Heart Center, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  6. 6Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
  7. 7Development and Aging Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
  8. 8Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA.
  1. §Corresponding author. E-mail: acammar3{at}jhmi.edu (A.C.); aengler{at}ucsd.edu (A.J.E.)
  • * Present address: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology; Center for Biomedical Engineering, Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA.

  • Present address: Department of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK.

  • Present address: Department of Biology, Iowa State University, Ames, IA 50011, USA.

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