Vol 7, Issue 288
A simple funding process attracts proven scientists who have never worked on asthma to study disease mechanisms and advance new targets for therapy.
- Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections
A new series of spectinomycin analogs with potency against drug-resistant bacterial pathogens was designed and developed with a structure-based approach and validated in vitro and in vivo.
- The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs
The cytoplasmic prolyl-tRNA synthetase of Plasmodium falciparum is a dual-stage therapeutic target for drug development.
- Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma
Marrow-infiltrating lymphocytes (MILs) may be used as adoptive cell therapy for multiple myeloma.
- Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model
Prolonged exposure to therapeutic doses of acetaminophen reduces testosterone production by human fetal testis xenografts in mice.
Naturally occurring S. aureus and C. bovis drive inflammation and immune deviation in murine eczematous dermatitis.
Grapefruit-derived nanoparticles coated with active leukocyte plasma membrane can target tumors and effectively deliver anticancer therapeutics.