Research ArticleInfectious Disease

Classic reaction kinetics can explain complex patterns of antibiotic action

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Science Translational Medicine  13 May 2015:
Vol. 7, Issue 287, pp. 287ra73
DOI: 10.1126/scitranslmed.aaa8760

Article Information

vol. 7 no. 287 287ra73

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Print ISSN: 
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History: 
  • Received for publication February 7, 2015
  • Accepted for publication March 13, 2015

Author Information

  1. Pia Abel zur Wiesch1,2,*,
  2. Sören Abel3,4,
  3. Spyridon Gkotzis5,
  4. Paolo Ocampo6,7,
  5. Jan Engelstädter8,
  6. Trevor Hinkley9,
  7. Carsten Magnus10,
  8. Matthew K. Waldor3,11,
  9. Klas Udekwu5 and
  10. Ted Cohen1,2,12
  1. 1Division of Global Health Equity, Brigham and Women’s Hospital and Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA.
  2. 2Department of Epidemiology of Microbial Diseases, Yale School of Public Health, 60 College Street, New Haven, CT 06510, USA.
  3. 3Division of Infectious Diseases, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
  4. 4Department of Pharmacy, UiT, The Arctic University of Norway, 9037 Tromsø, Norway.
  5. 5Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 17177 Stockholm, Sweden.
  6. 6Institute of Integrative Biology, ETH Zürich, Universitätsstrasse 16, 8092 Zürich, Switzerland.
  7. 7Department of Environmental Microbiology, EAWAG, Überlandstrasse 133, 8600 Dübendorf, Switzerland.
  8. 8School of Biological Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.
  9. 9School of Chemistry, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK.
  10. 10Institute of Medical Virology, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
  11. 11Howard Hughes Medical Institute, 181 Longwood Avenue, Boston, MA 02115, USA.
  12. 12Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
  1. *Corresponding author. E-mail: pzw{at}daad-alumni.de

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