ReviewTransplantation

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

Science Translational Medicine  25 Mar 2015:
Vol. 7, Issue 280, pp. 280rv2
DOI: 10.1126/scitranslmed.aaa6853

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Abstract

Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

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